Enzalutamide impurity A
Enzalutamide Carboxylic Acid Metabolite (M1)
CAS: 1242137-15-0
Molecular Formula: C20H13F4N3O3S
Enzalutamide impurity A - Names and Identifiers
Enzalutamide impurity A - Physico-chemical Properties
| Molecular Formula | C20H13F4N3O3S |
| Molar Mass | 451.39 |
| Density | 1.59±0.1 g/cm3(Predicted) |
| Melting Point | 210-212°C |
| Boling Point | 590.2±60.0 °C(Predicted) |
| Solubility | DMSO (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White |
| pKa | 2.94±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Light Sensitive |
| In vitro study | Enzalutamide is converted into its major metabolites, N-desmethyl enzalutamide and carboxylic acid enzalutamide, by cytochrome P450 (CYP) 3A4/5 and CYP2C8, respectively. N-desmethyl enzalutamide has clinically relevant anti-androgen capacities similar to enzalutamide, whereas carboxylic acid enzalutamide is inactive. |
Enzalutamide impurity A - Introduction
Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide are androgen receptor (AR) antagonists.
Last Update：2022-10-16 17:31:12
Enzalutamide impurity A - Reference Information
| Use | enzalutamide carboxylic acid is a carboxylic acid amine organic substance, which can be used as an impurity reference substance. |
| biological activity | Enzalutamide carbonic acid (MDV3100 carbonic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist. |
Last Update：2024-04-09 21:21:28
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View History
Enzalutamide impurity A
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-, [6R-[6α,7β(Z)]]-
二氟溴乙酰胺
2-氟-3-硝基苯甲酸
3-碘-8-甲基-咪唑并[1,2-A]吡啶
2-(4-甲氧基哌啶-1-基)-2-甲基丙-1-胺
ethyl 3-(5-methyl-1H-pyrazol-1-yl)propanoate
2-甲基-7,8-二氢吡啶并[3,2-d]嘧啶-5(6H)-羧酸叔丁酯
4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
1-溴-4-(3-氯丙氧基)苯
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-7-[[2-furanyl(methoxyimino)acetyl]amino]-8-oxo-, [6R-[6α,7β(Z)]]-
二氟溴乙酰胺
2-氟-3-硝基苯甲酸
3-碘-8-甲基-咪唑并[1,2-A]吡啶
2-(4-甲氧基哌啶-1-基)-2-甲基丙-1-胺
ethyl 3-(5-methyl-1H-pyrazol-1-yl)propanoate
2-甲基-7,8-二氢吡啶并[3,2-d]嘧啶-5(6H)-羧酸叔丁酯
4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid
1-溴-4-(3-氯丙氧基)苯